Oxytocin

An accumulating body of evidence demonstrates the crucial role of the neuropeptide hormone oxytocin (OT) in the modulation of social cognition and behaviour. However, OT is more than just a “social” neuropeptide as it’s also involved in the regulation of a number of other physiological systems. Indeed, oxytocin system dysfucntion may contribute to the overrepresentation of metabolic disorders in severe mental illnesses.

Remarkably, little work has explicitly investigated how the impact of OT on physiology influences social cognition and behaviour. Moreover, the role of the oxytocin gene pathway on psychological and physiological processess is poorly characterised. A better understanding of how the OT system influences the brain and body can help unravel the neurobiological basis of social function, and how this is linked to various physiological processes.

Publications

. Oxytocin gene networks in the human brain: A gene expression and large-scale fMRI meta-analysis study. Under review, 2018.

Preprint Code Dataset Project

. Low dose intranasal oxytocin delivered with Breath Powered device modulates pupil diameter and amygdala activity: a randomized controlled pupillometry and fMRI study . Neuropsychopharmacology, 2018.

PDF Project

. Evidence for intranasal oxytocin delivery to the brain: recent advances and future perspectives. Therapeutic Delivery, 2018.

Preprint PDF Project

. Saliva oxytocin measures do not reflect peripheral plasma concentrations after intranasal oxytocin administration in men. Hormones and Behavior, 2018.

Preprint PDF Project

. Dose-dependent social-cognitive effects of intranasal oxytocin delivered with novel Breath Powered device in adults with autism spectrum disorder: a randomized placebo-controlled double-blind crossover trial. Translational Psychiatry, 2017.

PDF Project Open Access

. The correlation between central and peripheral oxytocin concentrations: A systematic review and meta-analysis. Neuroscience & Biobehavioral Reviews, 2017.

PDF Code Dataset Project

. Oxytocin system dysfunction as a common mechanism underlying metabolic syndrome and psychiatric symptoms in schizophrenia and bipolar disorders.. Frontiers in Neuroendocrinology, 2017.

PDF Project

. Reliability of basal plasma vasopressin concentrations in healthy male adults. Acta Neuropsychiatrica, 2017.

PDF Project

. The impact of oxytocin administration on brain activity: a systematic review and meta-analysis protocol. Systematic Reviews, 2016.

PDF Project Open Access

. Contribution of oxytocin receptor polymorphisms to amygdala activation in schizophrenia spectrum disorders. British Journal of Psychiatry Open, 2016.

PDF Project Open Access

. Low dose oxytocin delivered intranasally with Breath Powered device affects social-cognitive behavior: a randomized 4-way crossover trial with nasal cavity dimension assessment. Translational Psychiatry, 2015.

PDF Project Video Open Access