Improving the precision of intranasal oxytocin research

We outline how the precision of intranasal oxytocin research can be improved by the complementary consideration of methodology, theory and reproducibility


Examining how the oxytocin system impacts mental states and physiology

Advances in the field of intranasal oxytocin research: lessons learned and future directions for clinical research

In this review we outline recent advances from human and animal research that provide converging evidence for functionally relevant effects of the intranasal oxytocin administration route, suggesting that direct nose-to-brain delivery underlies the behavioral effects of oxytocin on social cognition and behavior

Associations of loneliness and social isolation with cardiovascular and metabolic health: a systematic review and meta-analysis protocol

A growing number of studies suggest that social isolation and loneliness are associated with premature mortality and are more prevalent among people with mental illness than in the general population, outlining many potential paths to disease still …

Linking central gene expression patterns and mental states using transcriptomics and large-scale meta-analysis of fMRI data: A tutorial and example using the oxytocin signaling pathway

The measurement of gene expression levels in the human brain can help accelerate our understanding of complex mental states and psychiatric illnesses. Mental states are typically associated with whole-brain networks, however, gene expression levels …

Most oxytocin administration studies are statistically underpowered to reliably detect (or reject) a wide range of effect sizes

The neuropeptide oxytocin has attracted substantial research interest for its role in behaviour and cognition; however, the evidence for its effects have been mixed. Meta-analysis is viewed as the gold-standard for synthesizing evidence, but the …

Oxytocin modulation of self-referential processing is partly replicable and sensitive to oxytocin receptor genotype

Intranasal oxytocin (OXT) has been associated with effects on diverse social-emotional domains in humans, however progress towards a therapeutic application of OXT in disorders with social-emotion impairments is currently hampered by poor …

Oxytocin pathway gene networks in the human brain

Using voxel-by-voxel gene expression brain maps generated via human post-mortem tissue, this analysis revealed expression of critical oxytocin pathway genes (OXTR, OXT, CD38) are enriched in subcortical and olfactory regions. fMRI meta-analysis revealed that these oxytocin pathway gene maps correspond with the processing of anticipatory, appetitive, and aversive cognitive states.

Low-dose intranasal oxytocin delivered with Breath Powered device modulates pupil diameter and amygdala activity: a randomized controlled pupillometry and fMRI study

Little is known about how intranasally administered oxytocin reaches the brain and modulates social behavior and cognition. Pupil dilation is a sensitive index of attentional allocation and effort, and inter-individual variability in pupil diameter …

Evidence for intranasal oxytocin delivery to the brain: recent advances and future perspectives

The neuropeptide oxytocin plays an evolutionarily conserved role in mammalian social behavior. Despite striking effects on animal social behavior after intracerebroventricular drug delivery, this delivery mode is impractical in humans. Intranasal …